Sleep helps protect against non-alcoholic fatty liver

fatty liver, According to a new study, sleep consumption appears to be associated with the risk of non-alcoholic fatty liver disease (NAFLD),

but “catch-up” sleep reduces this risk.The findings will help researchers better understand NAFLD and the consequences of sleep-related illnesses. The report was published in the Annals of Hepatology.
NAFLD is a broad term for a wide range of conditions caused by excessive fat accumulation. This comes with an increased risk of other metabolic conditions such as diabetes and obesity. Sleep – and especially sleep duration – is better recognized for its role in a number of chronic conditions, wrote the corresponding author Sangheun Lee, Ph.D., of Catholic Kwandong University College. medicine in South Korea. Recent evidence suggests that the risk of NAFLD may be affected by sleep.

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“Inadequate sleep, as well as poor sleep quality, can be the cause of many pathophysiological processes associated with NAFLD,” the authors say. Although Lee and colleagues have stated that although the broad relationship between NAFLD and sleep duration has been investigated, there is little understanding of how certain sleep patterns affect (or may cause) NAFLD. The sleep pattern – weekend sleep (WCUS) – is a more common behavior, the authors said. This term refers to a pattern where there is not enough sleep during the work week, but then sleeps longer on weekends to weave.

The researchers decided to examine data from the Korea National Health and Nutrition Examination Survey, a survey of more than 100,000 South Korean patients enrolled between 2008 and 2019. The survey respondents were divided into three categories: patients who slept on average less than seven hours a night; patients who sleep less than seven hours a night on weekdays but more than seven hours a night on weekends; and patients who slept an average of more than seven hours a week.

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The researchers found a significant negative relationship between sleeping more than seven hours a night and the risk of NAFLD. Using a hepatic steatosis index (HSI) score of 36 or higher as an indicator of fatty liver, the researchers found that patients who missed seven hours of sleep were more likely to have fatty liver. If the authors used a recent subset of the data (which included weekly sleep behavior), they found the same association. The search is really for both male and female subjects.

Lee and colleagues said there are many possible factors in the relationship between NAFLD and sleep. They noted that the hypothalamic-pituitary-adrenal axis and the autonomic nervous system are key to the regulation of physical and mental health. “Cortisol, the inflammatory cytokines and norepinephrine that are the sources of these systems are associated with sleep variables such as total sleep time, sleep quality, sleep efficiency, and circadian midpoint,” the letter wrote. “Dysregulation of these changes caused by sleep changes may increase the risk of NAFLD.”

She added that sleep deprivation is related to leptin levels and leptin with metabolic disease. “Reducing sleep duration will reduce leptin levels and increase food reward system activity,” she said. “This will lead to increased calorie intake and weight gain.” Lee and colleagues observed that seven or more hours of sleep on weekends and weekends and WCUS were negatively associated with obesity in the study.

However, the researchers said it was unclear whether “trapping” sleep could increase the increased risk of NAFLD.

“There is no study showing how WCUS reduces hepatic steatosis in animal experiments and other clinical trials, however, we suggest that weekend sleep supplementation may reduce oxidative stress and hepatitis,” she wrote. Lee and colleagues concluded that further research was needed to determine a possible causal relationship between NAFLD and sleep. They say such research could lead to expanded treatment options for NAFLD, which is currently limited to weight loss and improving eating habits.